New Frontiers on Adjuvants Drug Strategies and Treatments in Periodontitis

Causes of the progression periodontitis such as an imbalance between immune response by host release inflammatory mediators in oral pathogenic dysbiotic biofilm have been identified. New insights on specific cell signaling pathways that appear during attracted attention researchers study new personalised approaches for treatment periodontitis. The gold standard non-surgical therapy involves removal supra and subgingival through professional scaling root planing (SRP) hygiene instructions. In order to improve periodontal clinical outcomes overcome limitations traditional SRP, additional adjuvants developed recent decades, including local or systemic antibiotics, antiseptics, probiotics, anti-inflammatory anti-resorptive drugs modulation therapies. This review is aimed update current evolution therapies management based adjunctive target Moreover, we discuss advances impact targeting epigenetic mechanisms a therapeutic success conclusion, future goal periodontology will be combine personalise treatments colonising microbial profile individual patient.